Basic Bioinformatics

This course emphasizes the hands-on application of bioinformatics methods to biological problems. Hidden Markov Models, Introduction to Next Generation Sequencing, Mapping protein-DNA, interactions: ChIP-Seq, Introduction to NGS analysis tools, Genome Sequencing, Transcriptome Sequencing: RNA-Seq. Students will gain experience in the application of existing software, as well as in combining approaches to answer specific biological questions. Sequence alignment, fast database search, profiles and motifs, comparative genomics, gene finding, phylogenetic trees, protein structure, functional characterization of proteins, expression anaylysis, computational proteomics.